Find information about common, infrequent and rare side effects of Doxycycline Hyclate Periodontal. She was put on doxycycline for a few weeks and the symptoms went away. But then the symptoms came back, not as severe but more pervasive. She does get pain in her joints, but many other places as well. pain in the stomach, side, or abdomen, possibly radiating to the back red skin lesions, often with a purple center redness and soreness of the eyes redness of the skin sore throat sores, ulcers, or white spots in the mouth or on the lips stomach cramps stomach pain or tenderness swelling of the feet or lower legs swollen, painful, or tender lymph glands in the neck, armpit, or groin tightness. I had asked a question before about Doxycycline Antibiotic. Now I have another question about the same medication. I had to stop taking Doxycycline because I started getting throat pain , and goes. Stay away from this medication !!, I started a 7 day course of doxy last week for a sinus problem. The following morning from taking the first tablet i developed an unusual calf pain, this then resonated to my ankles and some other areas like my arms. Take doxycycline exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. Learn about the potential side effects of doxycycline. Includes common and rare side effects information for consumers and healthcare professionals. Levaquin Calf pain, peptic ulcer, chest pain, shortness of breath, cardic Chest pain , calf pain, shortness of breath and.It took weeks to feel better, and this was after two days in the hosptial. the cardic unit because it felt like an elephant was sitting on my chest. Had a serious case of cellulitis and didn't go in until suffering 7 days of intense swelling/pain in my right calf. Prescribed doxycycline 100 mg twice daily. Summary. Calf pain with exercise is found among people who take Doxycycline, especially for people who are male, 60+ old , have been taking the drug for 1 month, also take medication Digoxin, and have Muscle spasms.